Human diseases of the SSU processome
نویسندگان
چکیده
منابع مشابه
Assembling a Protein-Protein Interaction Map of the SSU Processome from Existing Datasets
BACKGROUND The small subunit (SSU) processome is a large ribonucleoprotein complex involved in small ribosomal subunit assembly. It consists of the U3 snoRNA and ∼72 proteins. While most of its components have been identified, the protein-protein interactions (PPIs) among them remain largely unknown, and thus the assembly, architecture and function of the SSU processome remains unclear. METHO...
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Sequential events in macromolecular biosynthesis are often elegantly coordinated. The small ribosomal subunit (SSU) processome is a large ribonucleoprotein (RNP) required for processing of precursors to the small subunit RNA, the 18S, of the ribosome. We have found that a subcomplex of SSU processome proteins, the t-Utps, is also required for optimal rRNA transcription in vivo in the yeast Sacc...
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A growing body of documents shows that rising average global temperatures can be one of several causes of disease emergence and reemergence among human and animal populations. In this regard, climate mostly affects diseases caused by pathogens that spend part of their lifecycle outside of the host, exposed to the environment like water-borne diseases, food-borne pathogens, and vector-borne zoon...
متن کاملOrigin and Evolution of the Eukaryotic SSU Processome Revealed by a Comprehensive Genomic Analysis and Implications for the Origin of the Nucleolus
As a nucleolar complex for small-subunit (SSU) ribosomal RNA processing, SSU processome has been extensively studied mainly in Saccharomyces cerevisiae but not in diverse organisms, leaving open the question of whether it is a ubiquitous mechanism across eukaryotes and how it evolved in the course of the evolution of eukaryotes. Genome-wide survey and identification of SSU processome components...
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ژورنال
عنوان ژورنال: Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease
سال: 2014
ISSN: 0925-4439
DOI: 10.1016/j.bbadis.2013.11.004